In their quest to bring someone back to life, Edward and Alphonse ignore the basic rule of alchemy. In order to manipulate matter, something of equal cost must be sacrified in order to manipulate the new creation. As a result, Edward loses an arm and part of a leg. Alphonse's body is lost completely, but Edward manages to trap his soul in an armor suit.
Fullmetal Alchemist also won Best New Anime Series and Best Theme Song for 2005.